Preparation and characterization of electrosprayed daidzein-loaded PHBV microspheres

Scheithauer EC, Li W, Ding Y, Harhaus L, Roether J, Boccaccini AR (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Materials Letters Elsevier

Book Volume: 158

Pages Range: 66-69

DOI: 10.1016/j.matlet.2015.05.133

Abstract

Given that hormone therapy of osteoporosis with estrogen and progesterone may have potential negative side effects, there is a strong need of developing alternative solutions. Possible therapy alternatives involve the use of phytoestrogens such as daidzein. In this study, daidzein-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microspheres were prepared using electrospraying. The obtained microspheres had uniform surface morphology, and narrow particle size distribution with mean particle size of 4.8 μm. Daidzein was determined to be in amorphous state in the PHBV microspheres by differential scanning calorimetry analysis. Encapsulated daidzein was released with a low initial burst release (7.6% at 1 h) followed by a sustained release over a period of ~3 days. The developed PHBV microspheres with daidzein delivery function have potential applications in the treatment of osteoporosis and for bone tissue engineering.

Authors with CRIS profile

Ellen Corinna Scheithauer Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Wei Li Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Yaping Ding Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE)

How to cite

APA:

Scheithauer, E.C., Li, W., Ding, Y., Harhaus, L., Roether, J., & Boccaccini, A.R. (2015). Preparation and characterization of electrosprayed daidzein-loaded PHBV microspheres. Materials Letters, 158, 66-69. https://dx.doi.org/10.1016/j.matlet.2015.05.133

MLA:

Scheithauer, Ellen Corinna, et al. "Preparation and characterization of electrosprayed daidzein-loaded PHBV microspheres." Materials Letters 158 (2015): 66-69.

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