Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome

Mu J, Rampp S, Carrette E, Roessler K, Sommer B, Schmitt FC, De Tiege X, Hamer H, Boon P, Pauli E, Blümcke I, Zhou D, Buchfelder M, Stefan H (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Publisher: Elsevier

Book Volume: 23

Pages Range: 553-9

Journal Issue: 7

DOI: 10.1016/j.seizure.2014.04.006

Abstract

To evaluate the value of magnetoencephalography (MEG) source localization in localization of epileptic activities and predicting surgical outcome in frontal lobe epilepsies (FLE).Forty-six patients with presurgical MEG evaluation and intractable FLE surgery (28 male patients) were analyzed retrospectively with a mean follow-up of 5 years. Dipole analysis was performed for MEG source imaging (MSI). The localization of dipole clusters in relation to the dominant hemisphere, lesions, resection cavity and functional cortex were analyzed. The predictive value of MSI in respect to clinical outcome with long-term postoperative follow up was evaluated.Interictal focal epileptic activities were found in 82.6% (38/46) patients with monofocal activity 81.6% (31/38) and multifocal activities 18.4% (7/38). Seizure free rate was 47.9% at the mean follow-up of 5.0 ± 4.0 years (median 11.5, range 2-57). Seizure recurrence mainly occurred in the first 1 year after surgery. In the monofocal epileptic activity group, 58.1% (18/31) of the patients were seizure free, predicitng postoperative seizure freedom better than multifocal localization 0% (0/7) (p=0.028). Dipole clusters were completely resected in 70.9% of monofocal activity patients, which had higher seizure free rates compared to partial resection (p=0.002). In patients with surgery in the dominant hemisphere, seizure control was less likely (p=0.006).MSI contributes to the clinical prediction of postoperative outcome in FLE patients. MSI may non-invasively disclose early epileptogenic lesions, pointing to a resectable lesion, and it then facilitates shortcut route of presurgical evaluation.

Authors with CRIS profile

Involved external institutions

University Hospital Ghent Belgium (BE) Universitätsklinikum Magdeburg A.ö.R. Germany (DE) Université libre de Bruxelles (ULB) / Free University of Brussels Belgium (BE) Sichuan University (SCU) / 四川大学 China (CN)

How to cite

APA:

Mu, J., Rampp, S., Carrette, E., Roessler, K., Sommer, B., Schmitt, F.C.,... Stefan, H. (2014). Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome. Seizure-European Journal of Epilepsy, 23(7), 553-9. https://doi.org/10.1016/j.seizure.2014.04.006

MLA:

Mu, Jie, et al. "Clinical relevance of source location in frontal lobe epilepsy and prediction of postoperative long-term outcome." Seizure-European Journal of Epilepsy 23.7 (2014): 553-9.

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