Stößel A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P (2017)
Publication Type: Journal article, Original article
Publication year: 2017
Book Volume: 25
Pages Range: 3491-3499
Journal Issue: 13
DOI: 10.1016/j.bmc.2017.04.036
Dopamine D3 receptor-mediated networks have been associated with a wide range of neuropsychiatric diseases, drug addiction and food maintained behavior, which makes D3 a highly promising biological target. The previously described dopamine D3 receptor ligand FAUC 329 (1) showed protective effects against dopamine depletion in a MPTP mouse model of Parkinson's disease. We used the radioligand [(18)F]2, a [(18)F]fluoroethoxy substituted analog of the lead compound 1 as a molecular tool for visualization of D3-rich brain regions including the islands of Calleja. Furthermore, structural modifications are reported leading to the pyrimidylpiperazine derivatives 3 and 9 displaying superior subtype selectivity and preference over serotonergic receptors. Evaluation of the lead compound 1 on cocaine-seeking behavior in non-human primates showed a substantial reduction in cocaine self-administration behavior and food intake.
APA:
Stößel, A., Brox, R., Purkayastha, N., Hübner, H., Hocke, C., Prante, O., & Gmeiner, P. (2017). Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorganic & Medicinal Chemistry, 25(13), 3491-3499. https://doi.org/10.1016/j.bmc.2017.04.036
MLA:
Stößel, Anne, et al. "Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior." Bioorganic & Medicinal Chemistry 25.13 (2017): 3491-3499.
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