Sauer R, Gölitz P, Jacobi J, Schwab S, Linker R, Lee DH (2017)
Publication Type: Journal article
Publication year: 2017
Book Volume: 375
Pages Range: 76-79
DOI: 10.1016/j.jns.2017.01.046
Progressive multifocal leukoencephalopathy (PML) is a rare, opportunistic and often fatal disease of the CNS which may occur under immunosuppression in transplant patients. Brain stem PML is associated with a particularly bad prognosis. Here, we present a case of a renal transplant patient treated with mycophenolate mofetil (MMF) and tacrolimus who developed brain stem PML with limb ataxia, dysarthria and dysphagia. Diagnosis was established by typical MRI features and detection of JCV-DNA in the CSF. Immune reconstitution after stopping MMF and tacrolimus led to a complete and sustained remission of symptoms with improvement of the brain stem lesion over a follow-up over 20months. In summary, early detection of PML and consequent treatment may improve neurological outcomes even in brain stem disease with a notorious bad prognosis.
APA:
Sauer, R., Gölitz, P., Jacobi, J., Schwab, S., Linker, R., & Lee, D.-H. (2017). Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution. Journal of the Neurological Sciences, 375, 76-79. https://dx.doi.org/10.1016/j.jns.2017.01.046
MLA:
Sauer, Rolf, et al. "Good outcome of brain stem progressive multifocal leukoencephalopathy in an immunosuppressed renal transplant patient: Importance of early detection and rapid immune reconstitution." Journal of the Neurological Sciences 375 (2017): 76-79.
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