Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

Philippart A, Boccardi E, Pontiroli L, Beltrán AM, Inayat A, Vitale-Brovarone C, Schwieger W, Spiecker E, Boccaccini AR (2014)


Publication Language: English

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 96

Pages Range: 54-60

DOI: 10.4028/www.scientific.net/AST.96.54

Abstract

Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

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APA:

Philippart, A., Boccardi, E., Pontiroli, L., Beltrán, A.M., Inayat, A., Vitale-Brovarone, C.,... Boccaccini, A.R. (2014). Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities. Advances in Science and Technology, 96, 54-60. https://dx.doi.org/10.4028/www.scientific.net/AST.96.54

MLA:

Philippart, Anahi, et al. "Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities." Advances in Science and Technology 96 (2014): 54-60.

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