New role for the (pro)renin receptor in T-cell development
Geisberger S, Maschke U, Gebhardt M, Kleinewietfeld M, Manzel A, Linker R, Chidgey A, Dechend R, Nguyen G, Daumke O, Muller DN, Wright MD, Binger KJ (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 126
Pages Range: 504-7
Journal Issue: 4
DOI: 10.1182/blood-2015-03-635292
Abstract
The (pro)renin receptor (PRR) was originally thought to be important for regulating blood pressure via the renin-angiotensin system. However, it is now emerging that PRR has instead a generic role in cellular development. Here, we have specifically deleted PRR from T cells. T-cell-specific PRR-knockout mice had a significant decrease in thymic cellularity, corresponding with a 100-fold decrease in the number of CD4(+) and CD8(+) thymocytes, and a large increase in double-negative (DN) precursors. Gene expression analysis on sorted DN3 thymocytes indicated that PRR-deficient thymocytes have perturbations in key cellular pathways essential at the DN3 stage, including transcription and translation. Further characterization of DN T-cell progenitors leads us to propose that PRR deletion affects thymocyte survival and development at multiple stages; from DN3 through to DN4, double-positive, and single-positive CD4 and CD8. Our study thus identifies a new role for PRR in T-cell development.
Authors with CRIS profile
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Monash University
Australia (AU)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
France (FR)
Technische Universität Dresden
Germany (DE)
Germany (DE)
Monash University
Australia (AU)
Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
Germany (DE)
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
France (FR)
Technische Universität Dresden
Germany (DE)
How to cite
APA:
Geisberger, S., Maschke, U., Gebhardt, M., Kleinewietfeld, M., Manzel, A., Linker, R.,... Binger, K.J. (2015). New role for the (pro)renin receptor in T-cell development. Blood, 126(4), 504-7. https://doi.org/10.1182/blood-2015-03-635292
MLA:
Geisberger, Sabrina, et al. "New role for the (pro)renin receptor in T-cell development." Blood 126.4 (2015): 504-7.
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