A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria
Steinhoff BJ, Hamer H, Trinka E, Schulze-Bonhage A, Bien C, Mayer T, Baumgartner C, Lerche H, Noachtar S (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Elsevier
Book Volume: 108
Pages Range: 986-8
Journal Issue: 5
DOI: 10.1016/j.eplepsyres.2014.03.015
Abstract
Perampanel (PER) has been approved by the European Medicines Agency (EMA) for adjunctive treatment of patients with partial-onset seizures from age 12 years on. It has been introduced to the market in Germany and Austria in 2012. This cross-sectional observational study summarizes the clinical experience of nine centers with adjunctive PER. Patients were consecutively followed from the initiation of PER on. Only patients with a minimum observational period of six months (in case of ongoing treatment) were recruited. Efficacy data reflect the preceding three months at last observation, tolerability data were assessed at the last observation carried forward. 281 patients were included. After six months 169 were still on PER so that a retention rate of 60% resulted. 43 patients were seizure-free for the preceding 3 months (15%). Overall incidence of adverse events was 52.0%. The leading adverse events were somnolence (24.6%) and dizziness (19.6%) followed by ataxia (3.9%), aggression (2.8%), nausea (2.5%) and irritability (2.1%). We conclude that adjunctive PER may lead to at least temporary freedom of seizures in some of these highly difficult-to-treat patients. Adverse events are not uncommon.
Authors with CRIS profile
Involved external institutions
Salzburger Landeskliniken (SALK)
Austria (AT)
Universitätsklinikum Freiburg
Germany (DE)
Bethel Epilepsy Center
Germany (DE)
Kleinwachau - Sächsisches Epilepsiezentrum Radeberg gGmbH
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel
Austria (AT)
Epilepsiezentrum Kork
Germany (DE)
Austria (AT)
Universitätsklinikum Freiburg
Germany (DE)
Bethel Epilepsy Center
Germany (DE)
Kleinwachau - Sächsisches Epilepsiezentrum Radeberg gGmbH
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Ludwig-Maximilians-Universität (LMU)
Germany (DE)
Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel
Austria (AT)
Epilepsiezentrum Kork
Germany (DE)
How to cite
APA:
Steinhoff, B.J., Hamer, H., Trinka, E., Schulze-Bonhage, A., Bien, C., Mayer, T.,... Noachtar, S. (2014). A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria. Epilepsy Research, 108(5), 986-8. https://dx.doi.org/10.1016/j.eplepsyres.2014.03.015
MLA:
Steinhoff, Bernhard J., et al. "A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria." Epilepsy Research 108.5 (2014): 986-8.
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