Sodium chloride, SGK1, and Th17 activation
Binger KJ, Linker R, Muller DN, Kleinewietfeld M (2015)
Publication Type: Journal article, Review article
Publication year: 2015
Journal
Book Volume: 467
Pages Range: 543-50
Journal Issue: 3
DOI: 10.1007/s00424-014-1659-z
Abstract
The incidence of autoimmune diseases in Western civilizations is increasing rapidly, suggesting an influence of environmental factors, such as diet. The pathogenesis of several of these autoimmune diseases is characterized by aberrant activation of T helper 17 (Th17) cells. Recent reports have shown that the differentiation of Th17 cells is sensitive to changes in local microenvironments, in particular salt (NaCl) concentrations, in a molecular mechanism centered around the serum- and glucocorticoid-inducible kinase 1 (SGK1). In this review, we summarize the recently disclosed mechanisms by which salt has been shown to affect SGK1 and, subsequently, Th17 activation.
Authors with CRIS profile
Involved external institutions
Experimental and Clinical Research Center (ECRC)
Germany (DE)
Technische Universität Dresden
Germany (DE)
Germany (DE)
Technische Universität Dresden
Germany (DE)
How to cite
APA:
Binger, K.J., Linker, R., Muller, D.N., & Kleinewietfeld, M. (2015). Sodium chloride, SGK1, and Th17 activation. Pflügers Archiv: European Journal of Physiology, 467(3), 543-50. https://dx.doi.org/10.1007/s00424-014-1659-z
MLA:
Binger, Katrina J., et al. "Sodium chloride, SGK1, and Th17 activation." Pflügers Archiv: European Journal of Physiology 467.3 (2015): 543-50.
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