Journal article
(Review article)


The impact of microgravity-based proteomics research


Publication Details
Author(s): Grimm D, Pietsch J, Wehland M, Richter P, Strauch S, Lebert M, Magnusson NE, Wise P, Bauer J
Publication year: 2014
Volume: 11
Journal issue: 4
Pages range: 465-476
ISSN: 1744-8387

Abstract

Proteomics is performed in microgravity research in order to determine protein alterations occurring qualitatively and quantitatively, when single cells or whole organisms are exposed to real or simulated microgravity. To this purpose, antibody-dependent (Western blotting, flow cytometry, Luminex technology) and antibody-independent (mass spectrometry, gene array) techniques are applied. The anticipated findings will help to understand microgravity-specific behavior, which has been observed in bacteria, as well as in plant, animal and human cells. To date, the analyses revealed that cell cultures are more sensitive to microgravity than cells embedded in organisms and that proteins changing under microgravity are highly interactive. Furthermore, one has to distinguish between primary gravity-induced and subsequent interaction-dependent changes of proteins, as well as between direct microgravity-related effects and indirect stress responses. Progress in this field will impact on tissue engineering and medicine and will uncover possibilities of counteracting alterations of protein expression at lowered gravity. © 2014 Informa UK, Ltd.



How to cite
APA: Grimm, D., Pietsch, J., Wehland, M., Richter, P., Strauch, S., Lebert, M.,... Bauer, J. (2014). The impact of microgravity-based proteomics research. Expert Review of Proteomics, 11(4), 465-476. https://dx.doi.org/10.1586/14789450.2014.926221

MLA: Grimm, Daniela, et al. "The impact of microgravity-based proteomics research." Expert Review of Proteomics 11.4 (2014): 465-476.

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