Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions
Waschbisch A, Sammet L, Schröder S, Lee DH, Barrantes-Freer A, Stadelmann C, Linker R (2014)
Publication Type: Journal article
Publication year: 2014
Journal
Publisher: Wiley-Blackwell
Book Volume: 177
Pages Range: 404-11
Journal Issue: 2
DOI: 10.1111/cei.12345
Abstract
T cells with a CD4(+) CD8(+) double-positive (DP) phenotype are present in small numbers in the peripheral blood of healthy humans and may have anti-viral capacities. Here we investigate numbers and function of DP T cells in patients with relapsing-remitting multiple sclerosis (MS), either treatment-naive or under therapy with natalizumab. Flow cytometry analysis revealed that frequencies of circulating DP T cells in treatment-naive and natalizumab-treated MS patients are comparable to healthy controls. These cells have a memory phenotype with cytotoxic potential, express high levels of CD49d and are similarly functional in treatment-naive as well as natalizumab-treated MS patients. DP T cells were enriched in the cerebrospinal fluid, but do not invade acutely inflamed MS lesions. In conclusion, DP T cells are functional in MS and may play a role in the immune surveillance of the central nervous system, but do not display functional impairment under natalizumab therapy.
Authors with CRIS profile
Anne Waschbisch
Department of Neurology
Laura Sammet
Medizinische Fakultät
Ralf Linker
Department of Neurology
Involved external institutions
Germany (DE)How to cite
APA:
Waschbisch, A., Sammet, L., Schröder, S., Lee, D.-H., Barrantes-Freer, A., Stadelmann, C., & Linker, R. (2014). Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions. Clinical and Experimental Immunology, 177(2), 404-11. https://dx.doi.org/10.1111/cei.12345
MLA:
Waschbisch, Anne, et al. "Analysis of CD4+ CD8+ double-positive T cells in blood, cerebrospinal fluid and multiple sclerosis lesions." Clinical and Experimental Immunology 177.2 (2014): 404-11.
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