The age and genomic integrity of neurons after cortical stroke in humans

Huttner HB, Bergmann O, Salehpour M, Racz A, Tatarishvili J, Lindgren E, Csonka T, Csiba L, Hortobagyi T, Mehes G, Englund E, Solnestam BW, Zdunek S, Scharenberg C, Strom L, Stahl P, Sigurgeirsson B, Dahl A, Schwab S, Possnert G, Bernard S, Kokaia Z, Lindvall O, Lundeberg J, Frisen J (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Nature Neuroscience Nature Publishing Group

Publisher: Nature Publishing Group

Book Volume: 17

Pages Range: 801-3

Journal Issue: 6

DOI: 10.1038/nn.3706

Abstract

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

Authors with CRIS profile

Stefan Schwab Lehrstuhl für Neurologie

Involved external institutions

Karolinska Institute SE Sweden (SE) Uppsala University SE Sweden (SE) University of Debrecen / Debreceni Egyetem HU Hungary (HU) Skåne University Hospital / Skånes universitetssjukhus SE Sweden (SE) Royal Institute of Technology / Kungliga Tekniska Högskolan (KTH) SE Sweden (SE) Karolinska University Hospital / Karolinska Universitetssjukhuset SE Sweden (SE) Technische Universität Dresden DE Germany (DE) Université Claude Bernard Lyon 1 (UCB) FR France (FR)

How to cite

APA:

Huttner, H.B., Bergmann, O., Salehpour, M., Racz, A., Tatarishvili, J., Lindgren, E.,... Frisen, J. (2014). The age and genomic integrity of neurons after cortical stroke in humans. Nature Neuroscience, 17(6), 801-3. https://dx.doi.org/10.1038/nn.3706

MLA:

Huttner, Hagen B., et al. "The age and genomic integrity of neurons after cortical stroke in humans." Nature Neuroscience 17.6 (2014): 801-3.

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