Taeger C, Friedrich O, Drechsler C, Weigand A, Hobe F, Geppert CI, Münch F, Birkholz T, Buchholz R, Horch RE, Präbst K, Buchholz R (2016)
Publication Language: English
Publication Status: Published
Publication Type: Journal article
Publication year: 2016
DOI: 10.3233/CH-162049
In the field of free flap transfer in reconstructive surgery, the trans- or replanted tissue always undergoes cell damage during ischemia to a more or less strong extent. In previous studies we already showed that conserving muscle transplants by means of extracorporeal perfusion over a period of 6 hours by using a crystalloid solution for perfusion. However, we observed significant edema formation. In this study we aimed at reducing the edema formation by using an iso-oncotic colloid as perfusion solution. This way we want to evaluate a possible new application of hydroxyl-ethyl starch in an extracorporeal setup to exploit potential benefits of the colloid.Examined parameters include the muscles' functionality with external field stimulation, histological examination and edema formation. Perfused muscles showed a statistically significant higher ability to exert force compared to nonperfused ones. These findings can be confirmed using Annexin V as marker for cell damage, perfusion of muscle tissue limits damage significantly compared to nonperfused tissue. Substituting the electrolyte perfusion solution with a colloidal one shows the tendency to reduce the edema formation but without statistical significance.
APA:
Taeger, C., Friedrich, O., Drechsler, C., Weigand, A., Hobe, F., Geppert, C.-I.,... Buchholz, R. (2016). Hydroxyethyl starch solution for extracorporeal tissue perfusion. Clinical hemorheology and microcirculation. https://dx.doi.org/10.3233/CH-162049
MLA:
Taeger, Christian, et al. "Hydroxyethyl starch solution for extracorporeal tissue perfusion." Clinical hemorheology and microcirculation (2016).
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