Spooky sodium balance

Titze J, Dahlmann A, Lerchl K, Kopp C, Rakova N, Schröder A, Luft FC (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

Publisher: Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 85

Pages Range: 759-67

Journal Issue: 4

DOI: 10.1038/ki.2013.367

Abstract

Current teaching states that when sodium intake is increased from low to high levels, total-body sodium (TBNa) and water increase until daily sodium excretion again equals intake. When sodium intake is reduced, sodium excretion briefly exceeds intake until the excess TBNa and water are eliminated, at which point sodium excretion again equals intake. However, careful balance studies oftentimes conflict with this view and long-term studies suggest that TBNa fluctuates independent of intake or body weight. We recently performed the opposite experiment in that we fixed sodium intake for several weeks at three levels of sodium intake and collected all urine made. We found weekly (circaseptan) patterns in sodium excretion that were inversely related to aldosterone and directly to cortisol. TBNa was not dependent on sodium intake but instead exhibited far longer (>= monthly) infradian rhythms independent of extracellular water, body weight, or blood pressure. The findings are consistent with our ideas on tissue sodium storage and its regulation that we developed on the basis of animal research. We are implementing (23)Na-magnetic resonance imaging (MRI) to pursue open questions on sodium balance in patients. Our findings could be relevant to therapeutic strategies for hypertension and target-organ damage.

Authors with CRIS profile

Jens Titze Professur für Elektrolyt- und Kreislaufforschung Kathrin Jüttner Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Agnes Schröder Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien

Involved external institutions

Vanderbilt University US United States (USA) (US)

How to cite

APA:

Titze, J., Dahlmann, A., Lerchl, K., Kopp, C., Rakova, N., Schröder, A., & Luft, F.C. (2014). Spooky sodium balance. Kidney International, 85(4), 759-67. https://dx.doi.org/10.1038/ki.2013.367

MLA:

Titze, Jens, et al. "Spooky sodium balance." Kidney International 85.4 (2014): 759-67.

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