Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage

Huhn K, Lämmer R, Oberwahrenbrock T, Laemmer A, Waschbisch A, Gosar D, Brandt A, Paul F, Linker RA, Lee DH (2015)

Publication Type: Journal article

Publication year: 2015

Journal

European Journal of Neurology Wiley-Blackwell

Publisher: Wiley-Blackwell

Book Volume: 22

Pages Range: 86-92

Journal Issue: 1

DOI: 10.1111/ene.12532

Abstract

Some 3%-10% of patients with multiple sclerosis (MS) experience disease onset before the age of 18 years ('early' onset MS, EOMS). Optical coherence tomography is a non-invasive method to measure retinal nerve fibre layer thickness (RNFLT) and total macular volume (TMV) and may be useful to differentiate axonal and neuronal damage in the retina of patients with a history of EOMS. Here RNFLT and TMV in EOMS patients after a mean disease duration of 11.6 years were compared with patients with age- or disease-duration-matched later onset MS (LOMS) and healthy controls (HCs).In this observational cross-sectional study at two German academic MS centres, RNFLT and TMV were measured by spectral-domain optical coherence tomography in 32 HCs, 36 EOMS (mean age at onset 15.5 ± 2.0 years) and 58 LOMS patients.In comparison with HCs, EOMS patients displayed a significant reduction of RNFLT and TMV independently of a history of optic neuritis. In particular, RNFLT loss in EOMS was similar to that in LOMS and TMV loss was slightly higher compared with disease-duration-matched LOMS. In a generalized estimating model, the EOMS group also displayed a similar correlation between disease duration and RNFLT or TMV loss to LOMS patients.These data argue for a significant amount of axonal and neuronal damage in the retina of EOMS patients and may provide a structural basis for the observation that EOMS patients reach states of irreversible disability at a younger age than patients with LOMS.

Authors with CRIS profile

Robert Lämmer Professur für Augenheilkunde (Glaukome) Anne Waschbisch Department of Neurology

Involved external institutions

Max-Delbrück-Centrum für Molekulare Medizin / Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch DE Germany (DE)

How to cite

APA:

Huhn, K., Lämmer, R., Oberwahrenbrock, T., Laemmer, A., Waschbisch, A., Gosar, D.,... Lee, D.-H. (2015). Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage. European Journal of Neurology, 22(1), 86-92. https://dx.doi.org/10.1111/ene.12532

MLA:

Huhn, K., et al. "Optical coherence tomography in patients with a history of juvenile multiple sclerosis reveals early retinal damage." European Journal of Neurology 22.1 (2015): 86-92.

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