The evaluation of physical properties and in vitro cell behavior of PHB/PCL/sol-gel derived silica hybrid scaffolds and PHB/PCL/fumed silica composite scaffolds

Ding Y, Yao Q, Li W, Schubert DW, Boccaccini AR, Roether J (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Colloids and Surfaces B: Biointerfaces Elsevier

Book Volume: 136

Pages Range: 93-98

DOI: 10.1016/j.colsurfb.2015.08.023

Abstract

PHB/PCL/sol-gel derived silica hybrid scaffolds (P5S1S) and PHB/PCL/fumed silica composite scaffolds (P5S1N) with a 5:1 organic/inorganic ratio were fabricated through a combination of electrospinning and sol-gel methods and dispersion electrospinning, respectively. In contrast to the silica nanoparticle aggregates appearing on the fiber surface of P5S1N, smooth and uniform fibers were obtained for P5S1S. The fiber diameter distribution, tensile strength, thermal gravimetric analysis (TGA), and cellular behavior of both types of scaffolds were characterized and studied. The tensile strength results and TGA indicated that the interfacial interaction between the organic and the inorganic phase was enhanced in P5S1S over the nanocomposite scaffolds, and cells exhibited significantly higher alkaline phosphate activity (ALP) for P5S1S, which makes P5S1S hybrid scaffolds candidate materials for bone tissue engineering applications.

Authors with CRIS profile

Yaping Ding Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Wei Li Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)

Involved external institutions

Wenzhou Medical University / 温州医科大学 (WMU) CN China (CN)

How to cite

APA:

Ding, Y., Yao, Q., Li, W., Schubert, D.W., Boccaccini, A.R., & Roether, J. (2015). The evaluation of physical properties and in vitro cell behavior of PHB/PCL/sol-gel derived silica hybrid scaffolds and PHB/PCL/fumed silica composite scaffolds. Colloids and Surfaces B: Biointerfaces, 136, 93-98. https://dx.doi.org/10.1016/j.colsurfb.2015.08.023

MLA:

Ding, Yaping, et al. "The evaluation of physical properties and in vitro cell behavior of PHB/PCL/sol-gel derived silica hybrid scaffolds and PHB/PCL/fumed silica composite scaffolds." Colloids and Surfaces B: Biointerfaces 136 (2015): 93-98.

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