A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation

Simpson RL, Nazhat SN, Blaker JJ, Bismarck A, Hill R, Boccaccini AR, Hansen UN, Amis AA (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Journal of the Mechanical Behavior of Biomedical Materials Elsevier

Publisher: Elsevier

Book Volume: 50

Pages Range: 277-289

DOI: 10.1016/j.jmbbm.2015.06.008

Abstract

Bone substitute composite materials with poly(L-lactide-co-glycolide) (PLGA) matrices and four different bioactive fillers: CaCO3, hydroxyapatite (HA), 4555 Bioglass (R) (45S5 BG), and ICIE4 bioactive glass (a lower sodium glass than 45S5 BG) were produced via melt blending, extrusion and moulding. The viscoelastic, mechanical and thermal properties, and the molecular weight of the matrix were measured. Thermogravimetric analysis evaluated the effect of filler composition on the thermal degradation of the matrix. Bioactive glasses caused premature degradation of the matrix during processing, whereas CaCO3 or HA did not. All composites, except those with 4555 BG, had similar mechanical strength and were stiffer than PLGA alone in compression, whilst all had a lower tensile strength. Dynamic mechanical analysis demonstrated an increased storage modulus (E') in the composites (other than the 45S5 BG filled PLGA). The effect of water uptake and early degradation was investigated by short-term in vitro aging in simulated body fluid, which indicated enhanced water uptake over the neat polymer; bioactive glass had the greatest water uptake, causing matrix plasticization. These results enable a direct comparison between bioactive filler type in poly(alpha-hydroxyester) composites, and have implications when selecting a composite material for eventual application in bone substitution. (C) 2015 Elsevier Ltd. All rights reserved.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Imperial College London / The Imperial College of Science, Technology and Medicine GB United Kingdom (GB) McGill University CA Canada (CA) University of Manchester GB United Kingdom (GB) Queen Mary, University of London GB United Kingdom (GB)

How to cite

APA:

Simpson, R.L., Nazhat, S.N., Blaker, J.J., Bismarck, A., Hill, R., Boccaccini, A.R.,... Amis, A.A. (2015). A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation. Journal of the Mechanical Behavior of Biomedical Materials, 50, 277-289. https://dx.doi.org/10.1016/j.jmbbm.2015.06.008

MLA:

Simpson, R. L., et al. "A comparative study of the effects of different bioactive fillers in PLGA matrix composites and their suitability as bone substitute materials: A thermo-mechanical and in vitro investigation." Journal of the Mechanical Behavior of Biomedical Materials 50 (2015): 277-289.

BibTeX: Download