Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering

Yao Q, Nooeaid P, Detsch R, Roether J, Dong Y, Goudouri OM, Schubert DW, Boccaccini AR (2014)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2014

Journal

Journal of Biomedical Materials Research Part A Wiley

Book Volume: 102

Pages Range: 4510-4518

Journal Issue: 12

DOI: 10.1002/jbm.a.35125

Abstract

Polymer-coated 45S5 Bioglass® (BG)/chitosan-polycaprolactone (BG/CS-PCL) bilayered composite scaffolds were prepared via foam replication and freeze-drying techniques for application in osteochondral tissue engineering. The CSPCL coated and uncoated BG scaffolds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The mechanical properties of the coated scaffolds were significantly improved in comparison to uncoated scaffolds. The bioactivity and biodegradation behavior of scaffolds were studied in simulated body fluid (SBF) for up to 28 days. The interface between the BG scaffold and the polymer coating layer was observed by SEM and a suitable interpenetration of the polymer into the scaffold struts was found. The effects of coated and uncoated BG scaffolds on MG-63 osteoblastlike cells were evaluated by cell viability, adhesion and proliferation.

Authors with CRIS profile

Patcharakamon Nooeaid Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Ourania Menti Goudouri Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Dirk Schubert Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Wenzhou Medical University / 温州医科大学 (WMU) CN China (CN) Xiamen University CN China (CN)

How to cite

APA:

Yao, Q., Nooeaid, P., Detsch, R., Roether, J., Dong, Y., Goudouri, O.M.,... Boccaccini, A.R. (2014). Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering. Journal of Biomedical Materials Research Part A, 102(12), 4510-4518. https://dx.doi.org/10.1002/jbm.a.35125

MLA:

Yao, Qingqing, et al. "Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering." Journal of Biomedical Materials Research Part A 102.12 (2014): 4510-4518.

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