Alginate-based hydrogels with improved adhesive properties for cell encapsulation

Sarker B, Rompf J, Silva R, Lang N, Detsch R, Kaschta J, Fabry B, Boccaccini AR (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Book Volume: 78

Pages Range: 72-78

DOI: 10.1016/j.ijbiomac.2015.03.061

Abstract

Hydrogel-based biomaterials are ideal scaffolding matrices for microencapsulation, but they need to be modified to resemble the mechanical, structural and chemical properties of the native extracellular matrix. Here, we compare the mechanical properties and the degradation behavior of unmodified and modified alginate hydrogels in which cell adhesive functionality is conferred either by blending or covalently cross-linking with gelatin. Furthermore, we measure the spreading and proliferation of encapsulated osteoblast-like MG-63 cells. Alginate hydrogels covalently crosslinked with gelatin show the highest degree of cell adhesion, spreading, migration, and proliferation, as well as a faster degradation rate, and are therefore a particularly suitable material for microencapsulation.

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How to cite

APA:

Sarker, B., Rompf, J., Silva, R., Lang, N., Detsch, R., Kaschta, J.,... Boccaccini, A.R. (2015). Alginate-based hydrogels with improved adhesive properties for cell encapsulation. International Journal of Biological Macromolecules, 78, 72-78. https://dx.doi.org/10.1016/j.ijbiomac.2015.03.061

MLA:

Sarker, Bapi, et al. "Alginate-based hydrogels with improved adhesive properties for cell encapsulation." International Journal of Biological Macromolecules 78 (2015): 72-78.

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