Bänsch E, Lee G, Reismann S (2014)
Publication Type: Journal article, Original article
Publication year: 2014
Publisher: Informa Healthcare
Book Volume: 19
Pages Range: 634-640
Journal Issue: 5
URI: http://www.pharmtech.uni-erlangen.de
DOI: 10.3109/10837450.2013.819016
A numerical solution of the one-dimensional diffusion equation is presented to describe the 5-layer laminate technique for estimating the saturation solubility of a drug in a thin polymer film. The boundary and initial conditions encompass a donor layer, a separating membrane, and an acceptor layer. Alteration of the drug's partition coefficient between donor and separating membrane has little influence on drug accumulation with the acceptor. The diffusivity in the separating membrane should be high to promote a short experimental time to achieve saturation equilibrium in the acceptor layer. The essential parameter to give rapid equilibrium is the thickness of the acceptor polymer film. For values of diffusivity typical for drugs of molecular weight around 500 an acceptor layer thickness of 10 μm-20 μm is required to achieve equilibrium within less than 10 d. These simulations allow the selection of suitable experimental conditions to make the 5-layer laminate technique a viable method for routine use. © 2014 Informa Healthcare USA, Inc.
APA:
Bänsch, E., Lee, G., & Reismann, S. (2014). Numerical Solution for 5-Layer Laminate Technique to determine Saturation Solubility of a Drug in a Thin Film of Pressure Sensitive Adhesive. Pharmaceutical Development and Technology, 19(5), 634-640. https://dx.doi.org/10.3109/10837450.2013.819016
MLA:
Bänsch, Eberhard, Geoffrey Lee, and Simone Reismann. "Numerical Solution for 5-Layer Laminate Technique to determine Saturation Solubility of a Drug in a Thin Film of Pressure Sensitive Adhesive." Pharmaceutical Development and Technology 19.5 (2014): 634-640.
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