An optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver

Riexinger A, Martin J, Wetscherek A, Kuder TA, Uder M, Hensel B, Laun FB (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Abstract

Purpose: To find an optimized b-value distribution for reproducible triexponential intravoxel incoherent motion (IVIM) exams in the liver. Methods: A numeric optimization of b-value distributions was performed using the triexponential IVIM equation and 27 different IVIM parameter sets. Starting with an initially optimized distribution of 6 b-values, the number of b-values was increased stepwise. Each new b-value was chosen from a set of 64 predefined b-values based on the computed summed relative mean error of the fitted triexponential IVIM parameters. This process was repeated for up to 100 b-values. In simulations and in vivo measurements, optimized b-value distributions were compared to 4 representative distributions found in literature. Results: The first 16 optimized b-values were 0, 0.3, 0.3, 70, 200, 800, 70, 1, 3.5, 5, 70, 1.2, 6, 45, 1.5, and 60 in units of s/mm². Low b-values were much more frequent than high b-values. The optimized b-value distribution resulted in a higher fit stability compared to distributions used in literature in both, simulation and in vivo measurements. Using more than 6 b-values, ideally 16 or more, increased the fit stability considerably. Conclusion: Using optimized b-values, the fit uncertainty in triexponential IVIM can be largely reduced. Ideally, 16 or more b-values should be acquired.

Authors with CRIS profile

Andreas Riexinger Institute of Radiology Jan Martin Max Schaldach-Stiftungsprofessur für Biomedizinische Technik Michael Uder Lehrstuhl für Diagnostische Radiologie Bernhard Hensel Max Schaldach-Stiftungsprofessur für Biomedizinische Technik Frederik Bernd Laun Professur für quantitative MR-Bildgebung (Heisenberg-Professur)

Involved external institutions

Deutsches Krebsforschungszentrum (DKFZ)

Germany (DE) The Institute of Cancer Research (ICR)

United Kingdom (GB)

How to cite

APA:

Riexinger, A., Martin, J., Wetscherek, A., Kuder, T.A., Uder, M., Hensel, B., & Laun, F.B. (2020). An optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver. Magnetic Resonance in Medicine. https://dx.doi.org/10.1002/mrm.28582

MLA:

Riexinger, Andreas, et al. "An optimized b-value distribution for triexponential intravoxel incoherent motion (IVIM) in the liver." Magnetic Resonance in Medicine (2020).

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