Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T

Gast L, Volker S, Utzschneider M, Linz P, Wilferth T, Müller M, Kopp C, Hensel B, Uder M, Nagel AM (2020)


Publication Type: Journal article

Publication year: 2020

Journal

DOI: 10.1002/mrm.28428

Abstract

Purpose: To validate the feasibility of quantitative combined potassium (39K) and sodium (23Na) MRI in human calf muscle tissue, as well as to evaluate the reproducibility of the apparent tissue potassium concentration (aTPC) and apparent tissue sodium concentration (aTSC) determination in healthy muscle tissue. Methods: Quantitative 23Na and 39K MRI acquisition protocols were implemented on a 7 T MR system. A double-resonant 23Na/39K birdcage RF coil was used. Measurements of human lower leg were performed in a total acquisition time of TANa = 10:54 min/TAK = 8:06 min and using a nominal spatial resolution of 2.5 × 2.5 × 15 mm3/7.5 × 7.5 × 30 mm3 for 23Na/39K MRI. Two aTSC and aTPC examinations in muscle tissue were performed during the same day on 10 healthy subjects. Results: The proposed acquisition and postprocessing workflow for 23Na and 39K MRI data sets provided reproducible aTSC and aTPC measurements. In human calf muscle tissue, the coefficient of variation between scan and re-scan was 5.7% for both aTSC and aTPC determination. Overall, mean values of aTSC = (17 ± 1) mM and aTPC = (85 ± 5) mM were measured. Moreover, for 39K in calf muscle tissue, (Formula presented.) components of (Formula presented.) = (1.2 ± 0.2) ms and (Formula presented.) = (7.9 ± 0.9) ms, as well as a residual quadrupolar interaction of (Formula presented.) = (143 ± 17) Hz, were determined. The fraction of the fast component was f = (58 ± 4)%. Conclusion: Using the presented measurement and postprocessing approach, a reproducible aTSC and aTPC determination using 23Na and 39K MRI at 7 T in human skeletal muscle tissue is feasible in clinically acceptable acquisition durations.

Authors with CRIS profile

Additional Organisation(s)

How to cite

APA:

Gast, L., Volker, S., Utzschneider, M., Linz, P., Wilferth, T., Müller, M.,... Nagel, A.M. (2020). Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.28428

MLA:

Gast, Lena, et al. "Combined imaging of potassium and sodium in human skeletal muscle tissue at 7 T." Magnetic Resonance in Medicine (2020).

BibTeX: Download