Detection of iv-gadolinium leakage from the cortical veins into the CSF using MR fingerprinting
Naganawa S, Nakane T, Kawai H, Taoka T, Kawaguchi H, Maruyama K, Murata K, Körzdörfer G, Pfeuffer J, Nittka M, Sone M (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 19
Pages Range: 141-146
Journal Issue: 2
DOI: 10.2463/mrms.mp.2019-0048
Abstract
Purpose: It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T2-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA. Materials: Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39–79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T1 and T2 values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s. Results: The mean T1 value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the non-leakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T1 values in the area of GBCA leakage and those in the non-leakage area. The mean T2 value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T2 values in the area of GBCA leakage and those in the non-leakage area. Conclusion: Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.
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APA:
Naganawa, S., Nakane, T., Kawai, H., Taoka, T., Kawaguchi, H., Maruyama, K.,... Sone, M. (2020). Detection of iv-gadolinium leakage from the cortical veins into the CSF using MR fingerprinting. Magnetic Resonance in Medical Sciences, 19(2), 141-146. https://dx.doi.org/10.2463/mrms.mp.2019-0048
MLA:
Naganawa, Shinji, et al. "Detection of iv-gadolinium leakage from the cortical veins into the CSF using MR fingerprinting." Magnetic Resonance in Medical Sciences 19.2 (2020): 141-146.
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