Home Publications Research Grants Inventions & Patents Awards Additional Research Activities Faculties & Institutions Research Areas

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, Ellinghaus E, Barker JN, Chandran V, Dand N, Duffin KC, Enerback C, Esko T, Franke A, Gladman DD, Hoffmann P, Kingo K, Koks S, Krueger GG, Lim HW, Metspalu A, Mrowietz U, Mucha S, Rahman P, Reis A, Tejasvi T, Trembath R, Voorhees JJ, Weidinger S, Weichenthal M, Wen X, Eriksson N, Kang HM, Hinds DA, Nair RP, Abecasis GR, Elder JT (2017)

---

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 8

Pages Range: 15382

DOI: 10.1038/ncomms15382

Abstract

Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size >39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NF?B cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including TH0, TH1 and TH17). The identified loci explain ~28% of the genetic heritability and generate a discriminatory genetic risk score (AUC=0.76 in our sample) that is significantly correlated with age at onset (p=2 × 10(-89)). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Tsoi, L.C., Stuart, P.E., Tian, C., Gudjonsson, J.E., Das, S., Zawistowski, M.,... Elder, J.T. (2017). Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nature Communications, 8, 15382. https://doi.org/10.1038/ncomms15382

MLA:

Tsoi, Lam C., et al. "Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants." Nature Communications 8 (2017): 15382.

BibTeX: Download