Journal article


Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders


Publication Details
Author(s): Welz F, Sanders J, Kuwert T, Maler J, Kornhuber J, Ritt P
Publication year: 2016
Volume: 55
Journal issue: 4
Pages range: 158-65
ISSN: 0029-5566

Abstract

It was reported from planar imaging studies that the cerebral uptake of injected 99mTc-HMPAO activity is about 4-7% in humans. Recent work has shown that modern SPECT/CT devices are able to quantify the tissue concentration of radioactivity in vivo in absolute units (Bq/ml), while avoiding the limitations of planar techniques. The aims of this study were (a) to determine the cerebral uptake of 99mTc-HMPAO in absolute units in SPECT/CT, (b) to investigate potential differences in absolute tracer uptake for patients suspected of dementia.We performed 99mTc-HMPAO SPECT/CT in 65 patients with suspected dementia. 99mTc-HMPAO uptake was determined using a previously published quantitative SPECT/CT protocol. The absolute HMPAO uptake and the results of a regionalized analysis were compared for MMSE and NINCDS-ADRDA based patient groups.The mean absolute uptake of 99mTc-HMPAO for our patient population was 4.3 ± 0.8% of the injected dose. The uptake, as well as the regionalized analysis yielded significantly different results for low (<=23) and high (>23) MMSE groups and also for some of the NINCDS-ADRDA groups.Our results show that the absolute cerebral uptake of 99mTc-HMPAO is in the range of previously reported results, obtained by planar techniques. Absolute uptake is significantly different between the patient groups.



How to cite
APA: Welz, F., Sanders, J., Kuwert, T., Maler, J., Kornhuber, J., & Ritt, P. (2016). Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders. Nuklearmedizin-Nuclear Medicine, 55(4), 158-65. https://dx.doi.org/10.3413/Nukmed-0765-15-09

MLA: Welz, Friedrich, et al. "Absolute SPECT/CT quantification of cerebral uptake of 99mTc-HMPAO for patients with neurocognitive disorders." Nuklearmedizin-Nuclear Medicine 55.4 (2016): 158-65.

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