Elementary immunology: Na(+) as a regulator of immunity

Schatz V, Neubert P, Schröder A, Binger K, Gebhard M, Mueller DN, Luft FC, Titze J, Jantsch J (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Pediatric Nephrology Springer Verlag (Germany)

Book Volume: 32

Pages Range: 201-210

Journal Issue: 2

DOI: 10.1007/s00467-016-3349-x

Abstract

The skin can serve as an interstitial Na(+) reservoir. Local tissue Na(+) accumulation increases with age, inflammation and infection. This increased local Na(+) availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity. In this review, we summarize available data on how NaCl affects various immune cells. We particularly focus on how salt promotes pro-inflammatory macrophage and T cell function and simultaneously curtails their regulatory and anti-inflammatory potential. Overall, these findings demonstrate that local Na(+) availability is a promising novel regulator of immunity. Hence, the modulation of tissue Na(+) levels bears broad therapeutic potential: increasing local Na(+) availability may help in treating infections, while lowering tissue Na(+) levels may be used to treat, for example, autoimmune and cardiovascular diseases.

Authors with CRIS profile

Agnes Schröder Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien Jens Titze Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Experimental and Clinical Research Center (ECRC)

Germany (DE) Universität Regensburg

Germany (DE) Baker Idi Heart And Diabetes Institute

Australia (AU)

How to cite

APA:

Schatz, V., Neubert, P., Schröder, A., Binger, K., Gebhard, M., Mueller, D.N.,... Jantsch, J. (2017). Elementary immunology: Na(+) as a regulator of immunity. Pediatric Nephrology, 32(2), 201-210. https://doi.org/10.1007/s00467-016-3349-x

MLA:

Schatz, Valentin, et al. "Elementary immunology: Na(+) as a regulator of immunity." Pediatric Nephrology 32.2 (2017): 201-210.

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