Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD

Schneider MP, Raff U, Kopp C, Scheppach JB, Toncar S, Wanner C, Schlieper G, Saritas T, Floege J, Schmid M, Birukov A, Dahlmann A, Linz P, Janka RM, Uder M, Schmieder R, Titze J, Eckardt KU (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Journal of the American Society of Nephrology American Society of Nephrology

DOI: 10.1681/ASN.2016060662

Abstract

The pathogenesis of left ventricular hypertrophy in patients with CKD is incompletely understood. Sodium intake, which is usually assessed by measuring urinary sodium excretion, has been inconsistently linked with left ventricular hypertrophy. However, tissues such as skin and muscle may store sodium. Using (23)sodium-magnetic resonance imaging, a technique recently developed for the assessment of tissue sodium content in humans, we determined skin sodium content at the level of the calf in 99 patients with mild to moderate CKD (42 women; median [range] age, 65 [23-78] years). We also assessed total body overhydration (bioimpedance spectroscopy), 24-hour BP, and left ventricular mass (cardiac magnetic resonance imaging). Skin sodium content, but not total body overhydration, correlated with systolic BP (r=0.33, P=0.002). Moreover, skin sodium content correlated more strongly than total body overhydration did with left ventricular mass (r=0.56, P<0.001 versus r=0.35, P<0.001; P<0.01 between the two correlations). Linear regression analysis demonstrated that skin sodium content is a strong explanatory variable for left ventricular mass, unaffected by BP and total body overhydration. In conclusion, we found skin sodium content to be closely linked to left ventricular mass in patients with CKD. Interventions that reduce skin sodium content might improve cardiovascular outcomes in these patients.

Authors with CRIS profile

Anke Dahlmann Department of Medicine 4 – Nephrology and Hypertension Peter Linz Institute of Radiology Rolf Matthias Janka Institute of Radiology Michael Uder Lehrstuhl für Diagnostische Radiologie Roland Schmieder Professur für Innere Medizin (Nephrologie) Jens Titze Department of Medicine 4 – Nephrology and Hypertension Kai-Uwe Eckardt Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen DE Germany (DE) Julius-Maximilians-Universität Würzburg DE Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE)

How to cite

APA:

Schneider, M.P., Raff, U., Kopp, C., Scheppach, J.B., Toncar, S., Wanner, C.,... Eckardt, K.-U. (2017). Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD. Journal of the American Society of Nephrology. https://dx.doi.org/10.1681/ASN.2016060662

MLA:

Schneider, Markus P., et al. "Skin Sodium Concentration Correlates with Left Ventricular Hypertrophy in CKD." Journal of the American Society of Nephrology (2017).

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