Journal article
(Original article)

Radical arylation of tyrosine residues in peptides

Publication Details
Author(s): Fehler S, Pratsch G, Östreicher C, Fürst M, Pischetsrieder M, Heinrich M
Journal: Tetrahedron
Publisher: Elsevier Ltd
Publication year: 2016
Volume: 72
Journal issue: 48
Pages range: 7888-7893
ISSN: 1464-5416


The radical arylation of the phenolic side chain of tyrosine in peptides was investigated. Aryl radicals were generated from aryldiazonium salts using titanium(III) chloride as stoichiometric reductant. Due to the high selectivity with which 3-aryltyrosine derivatives were formed, this reaction type represents a new strategy for the direct functionalization of peptides.

How to cite
APA: Fehler, S., Pratsch, G., Östreicher, C., Fürst, M., Pischetsrieder, M., & Heinrich, M. (2016). Radical arylation of tyrosine residues in peptides. Tetrahedron, 72(48), 7888-7893.

MLA: Fehler, Stefanie, et al. "Radical arylation of tyrosine residues in peptides." Tetrahedron 72.48 (2016): 7888-7893.

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