Journal article
(Original article)


Fabrication of a turbid optofluidic phantom device with tunable µa and μ s’ to simulate cutaneous vascular perfusion


Publication Details
Author(s): Chen C, Ahmed M, Häfner T, Klämpfl F, Stelzle F, Schmidt M
Publisher: Nature Publishing Group: Open Access Journals - Option B
Publication year: 2016
ISSN: 2045-2322
Language: English

Abstract

Microfluidic devices are oftenly used to calibrate the imaging reconstruction, because they simulate the morphology of microvasculature. However, for lack of optical properties in microfluidics, the functional recovery of oximetry information cannot be verified. In this work, we describe the fabrication of a novel turbid optofluidic tissue phantom. It is designed to mimic the vascular perfusion and the turbid nature of cutaneous tissue. This phantom contains an interior hollow microfluidic structure with a diameter of ϕave = 50 μm. The microfluidic structure includes the geometry of an inlet, a river-like assay and an outlet. This structure can be perfused by hemoglobin solution to mimic the cutaneous micro-circulation. The multiple-layered phantom matrices exhibit the representative optical parameters of human skin cutis, namely the absorption coefficient μa and the reduced scattering coefficient . The geometry of the generated microfluidic structure is investigated by using Spectral-Domain Optical Coherence Tomography. This optofluidic phantom bridges the gap between tissue equivalent phantoms and Lab-On-Chip devices. Perspectively, this device can be used to calibrate a variety of optical angiographic imaging approaches.



How to cite
APA: Chen, C., Ahmed, M., Häfner, T., Klämpfl, F., Stelzle, F., & Schmidt, M. (2016). Fabrication of a turbid optofluidic phantom device with tunable µa and μ s’ to simulate cutaneous vascular perfusion. Scientific Reports. https://dx.doi.org/10.1038/srep30567

MLA: Chen, Chen, et al. "Fabrication of a turbid optofluidic phantom device with tunable µa and μ s’ to simulate cutaneous vascular perfusion." Scientific Reports (2016).

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