Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface

Neacsu P, Mazare AV, Cimpean A, Park JH, Costache M, Schmuki P, Demetrescu I (2014)

Publication Type: Journal article

Publication year: 2014

Journal

International Journal of Biochemistry & Cell Biology Elsevier

Publisher: Elsevier

Book Volume: 55

Pages Range: 187-95

DOI: 10.1016/j.biocel.2014.09.006

Abstract

Macrophages play a pivotal role in the hosts response to biomaterials being considered as an essential cell type during both optimal tissue-implant integration and pathologic process of implant failure. Hence, understanding of their cellular activity on biomaterials is important for improving evaluation and design of biomaterials for biomedical applications. In the present study, we have comparatively investigated the interactions of titania nanotubes (78 nm diameter) and commercial pure Ti with RAW 264.7 macrophages in both standard and pro-inflammatory (stimulation with lipopolysaccharide, LPS) culture conditions. In vitro tests showed that TiO2 nanotubes exhibited significantly decreased inflammatory activity of macrophages with respect to cytokine and chemokine gene expression/protein secretion, induction of foreign body giant cells (FBGCs) and nitric oxide (NO) release thereby mitigating the inflammatory response induced by LPS as compared to flat Ti surface. Therefore, our results suggest a novel role of TiO2 nanotubes in modulating macrophage response in biomaterial-associated bacterial infections. Overall, the current study provides new insight into how TiO2 nanotubes can be involved in macrophage activation and supports the great promise of such surface modifications for biomedical applications.

Authors with CRIS profile

Anca Valentina Mazare Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Jung Hyun Park Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik) Patrik Schmuki Lehrstuhl für Werkstoffwissenschaften (Korrosion und Oberflächentechnik)

Additional Organisation(s)

Department of Paediatrics and Adolescent Medicine

Involved external institutions

University of Bucharest / Universitatea din București RO Romania (RO) Politechnic University of Bucharest / Universitatea Politehnica din București RO Romania (RO)

How to cite

APA:

Neacsu, P., Mazare, A.V., Cimpean, A., Park, J.H., Costache, M., Schmuki, P., & Demetrescu, I. (2014). Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface. International Journal of Biochemistry & Cell Biology, 55, 187-95. https://doi.org/10.1016/j.biocel.2014.09.006

MLA:

Neacsu, Patricia, et al. "Reduced inflammatory activity of RAW 264.7 macrophages on titania nanotube modified Ti surface." International Journal of Biochemistry & Cell Biology 55 (2014): 187-95.

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