Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs

Pischetsrieder M, Gensberger-Reigl S, Atzenbeck L, Weigel I (2016)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2016

Journal

Drug Discovery Today Elsevier

Publisher: Elsevier

Book Volume: 21

Pages Range: 1620-1631

Journal Issue: 10

DOI: 10.1016/j.drudis.2016.06.011

Abstract

Carbohydrate degradation products are formed during heat sterilization in
drugs containing (poly-)glucose as osmotic agents. Given this situation,
peritoneal dialysis fluids (PDFs) and infusion fluids are of particular
clinical relevance, because these drugs deliver process contaminants either
over a longer period or directly into the circulation of patients who are
critically ill. For the development of suitable mitigation strategies, it is
important to understand the reaction mechanisms of carbohydrate
degradation during sterilization and how the resulting products interact
with physiological targets at the molecular level. Furthermore, reliable,
comprehensive, and highly sensitive quantification methods are required
for product control and toxicological evaluation.

Authors with CRIS profile

Monika Pischetsrieder Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Sabrina Gensberger-Reigl Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl) Lisa Atzenbeck Lehrstuhl für Lebensmittelchemie (Henriette-Schmidt-Burkhardt Lehrstuhl)

Additional Organisation(s)

Emil-Fischer-Zentrum (Emil Fischer Center)

Related research project(s)

None - None

How to cite

APA:

Pischetsrieder, M., Gensberger-Reigl, S., Atzenbeck, L., & Weigel, I. (2016). Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs. Drug Discovery Today, 21(10), 1620-1631. https://dx.doi.org/10.1016/j.drudis.2016.06.011

MLA:

Pischetsrieder, Monika, et al. "Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs." Drug Discovery Today 21.10 (2016): 1620-1631.

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