Journal article
(Review article)


Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs


Publication Details
Author(s): Pischetsrieder M, Gensberger-Reigl S, Atzenbeck L, Weigel I
Publisher: Elsevier
Publication year: 2016
Volume: 21
Journal issue: 10
Pages range: 1620-1631
ISSN: 1359-6446
Language: English

Abstract

Carbohydrate degradation products are formed during heat sterilization in
drugs containing (poly-)glucose as osmotic agents. Given this situation,
peritoneal dialysis fluids (PDFs) and infusion fluids are of particular
clinical relevance, because these drugs deliver process contaminants either
over a longer period or directly into the circulation of patients who are
critically ill. For the development of suitable mitigation strategies, it is
important to understand the reaction mechanisms of carbohydrate
degradation during sterilization and how the resulting products interact
with physiological targets at the molecular level. Furthermore, reliable,
comprehensive, and highly sensitive quantification methods are required
for product control and toxicological evaluation.



How to cite
APA: Pischetsrieder, M., Gensberger-Reigl, S., Atzenbeck, L., & Weigel, I. (2016). Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs. Drug Discovery Today, 21(10), 1620-1631. https://dx.doi.org/10.1016/j.drudis.2016.06.011

MLA: Pischetsrieder, Monika, et al. "Chemistry and Clinical Relevance of Carbohydrate Degradation in Drugs." Drug Discovery Today 21.10 (2016): 1620-1631.

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