Journal article
(Original article)


Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography


Publication Details
Author(s): Novais EA, Adhi M, Moult EM, Louzada RN, Cole ED, Husvogt L, Lee B, Dang S, Regatieri CVS, Witkin AJ, Baumal CR, Hornegger J, Jayaraman V, Fujimoto JG, Duker JS, Waheed NK
Publication year: 2016
Volume: 164
Pages range: 80-88
ISSN: 1879-1891

Abstract

Purpose To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultrahigh-speed swept-source (SS) optical coherence tomography angiography (OCTA) prototype vs a spectral-domain (SD) OCTA device. Design Comparative analysis of diagnostic instruments. Methods Patients were prospectively recruited to be imaged on SD OCT and SS OCT devices on the same day. The SD OCT device employed is the RTVue Avanti (Optovue, Inc, Fremont, California, USA), which operates at ∼840 nm wavelength and 70 000 A-scans/second. The SS OCT device used is an ultrahigh-speed long-wavelength prototype that operates at ∼1050 nm wavelength and 400 000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the 2 devices. The nonparametric Wilcoxon signed rank test was used to compare area measurements and P values of <.05 were considered statistically significant. Results Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type 1, 2 eyes (14.3%) as type 2, and 1 eye (7.1%) as mixed type. Total CNV area measured using SS OCT and SD OCT 3 mm × 3 mm OCTA were 0.949 ± 1.168 mm and 0.340 ± 0.301 mm, respectively (P =.001). For the 6 mm × 6 mm OCTA the total CNV area using SS OCT and SD OCT were 1.218 ± 1.284 mm and 0.604 ± 0.597 mm, respectively (P =.0019). The field of view did not significantly affect the measured CNV area (P =.19 and P =.18 for SS OCT and SD OCT, respectively). Conclusion SS OCTA yielded significantly larger CNV areas than SD OCTA. It is possible that SS OCTA is better able to demarcate the full extent of CNV vasculature.



How to cite
APA: Novais, E.A., Adhi, M., Moult, E.M., Louzada, R.N., Cole, E.D., Husvogt, L.,... Waheed, N.K. (2016). Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography. American Journal of Ophthalmology, 164, 80-88. https://dx.doi.org/10.1016/j.ajo.2016.01.011

MLA: Novais, Eduardo A., et al. "Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography." American Journal of Ophthalmology 164 (2016): 80-88.

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