Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration

Goudouri OM, Vogel C, Grünewald A, Detsch R, Kontonasaki E, Boccaccini AR (2016)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2016

Journal

Journal of Biomaterials Applications SAGE Publications

Book Volume: 30

Pages Range: 740-749

Journal Issue: 6

DOI: 10.1177/0885328215584887

Abstract

Periodontal tissue regeneration is an important application area of biomaterials, given the large proportion of the population affected by periodontal diseases like periodontitis. The aim of this study was the synthesis of a novel porous bioceramic scaffold in the SiO-CaO-MgO system with specific properties targeted for alveolar bone tissue regeneration using a modification of the traditional foam replica technique. Since bioceramic scaffolds are considered brittle, scaffolds were also coated with gelatin in order to increase their mechanical stability. Gelatin was chosen for its biocompatibility, biodegradability, low-cost, and low immunogenicity. However, gelatin degrades very fast in water solutions. For this reason, two different cross-linking agents were evaluated. Genipin, a non-toxic gardenia extract and the chemical compound 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) in combination with N-hydroxysuccinimide (NHS), which is also considered non-toxic. The results of the investigation indicated that all scaffolds presented an open, interconnected porosity and pores' sizes in the range of 300-600 1/4m, fast apatite-forming ability, biocompatibility, and suitable mechanical stability.

Authors with CRIS profile

Ourania Menti Goudouri Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Aristotle University of Thessaloniki GR Greece (GR)

How to cite

APA:

Goudouri, O.M., Vogel, C., Grünewald, A., Detsch, R., Kontonasaki, E., & Boccaccini, A.R. (2016). Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration. Journal of Biomaterials Applications, 30(6), 740-749. https://dx.doi.org/10.1177/0885328215584887

MLA:

Goudouri, Ourania Menti, et al. "Sol-gel processing of novel bioactive Mg-containing silicate scaffolds for alveolar bone regeneration." Journal of Biomaterials Applications 30.6 (2016): 740-749.

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