45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity

Stevanovic M, Filipovic N, Djurdjevic J, Lukic M, Milenkovic M, Boccaccini AR (2015)

Publication Status: Published

Publication Type: Journal article, Original article

Publication year: 2015

Journal

Colloids and Surfaces B-Biointerfaces Elsevier

Publisher: Elsevier

Book Volume: 132

Pages Range: 208-215

DOI: 10.1016/j.colsurfb.2015.05.024

Abstract

In the bone tissue engineering field, there is a growing interest in the application of bioactive glass scaffolds (45S5Bioglass®) due to their bone bonding ability, osteoconductivity and osteoinductivity. However, such scaffolds still lack some of the required functionalities to enable the successful formation of new bone, e.g. effective antibacterial properties. A large number of studies suggest that selenium (Se) has significant role in antioxidant protection, enhanced immune surveillance and modulation of cell proliferation. Selenium nanoparticles (SeNp) have also been reported to possess antibacterial as well as antiviral activities. In this investigation, uniform, stable, amorphous SeNp have been synthesized and additionally immobilized within spherical PLGA particles (PLGA/SeNp). These particles were used to coat bioactive glass-based scaffolds synthesized by the foam replica method. Samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and transmission electron microscopy (TEM). SeNp, 45S5Bioglass®/SeNp and 45S5Bioglass®/PLGA/SeNp showed a considerable antibacterial activity against Gram positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis, one of the main causative agents of orthopedic infections. The functionalized Se-coated bioactive glass scaffolds represent a new family of bioactive, antibacterial scaffolds for bone tissue engineering applications.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Serbian Academy of Sciences and Arts / Српска академија наука и уметности (САНУ) RS Serbia (RS) University of Belgrade / Универзитет у Београду RS Serbia (RS)

How to cite

APA:

Stevanovic, M., Filipovic, N., Djurdjevic, J., Lukic, M., Milenkovic, M., & Boccaccini, A.R. (2015). 45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity. Colloids and Surfaces B-Biointerfaces, 132, 208-215. https://dx.doi.org/10.1016/j.colsurfb.2015.05.024

MLA:

Stevanovic, Magdalena, et al. "45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity." Colloids and Surfaces B-Biointerfaces 132 (2015): 208-215.

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