Journal article
(Original article)


Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair


Publication Details
Author(s): Miguez Pacheco V, Büttner T, Macon ALB, Jones JR, Fey T, de Ligny D, Greil P, Chevalier J, Malchere A, Boccaccini A
Publisher: Elsevier
Publication year: 2016
Volume: 432
Pages range: 65-72
ISSN: 0022-3093
Language: English

Abstract

Incorporation of therapeutic ions into the structure of bioactive glasses for direct stimulation of cells is a very attractive approach for tissue engineering strategies. Lithium has recently been identified as a biologically active ion which can stimulate osteoblast cell activity. In this study, lithium-containing bioactive glasses (Li-BGs) where Li2O substitutes Na2O in different amounts (2.5, 5 and 10 wt.% Li2O) in 45S5 bioactive glass (BC) were produced and made into 3D scaffolds by the foam replica method. The structural changes that occur after heat treatment, the effect of lithium-content on the bioactivity of the glasses and their lithium ion release profiles were investigated. The results show that the novel Li-BC formulations exhibit the formation of an apatite-like layer on their surface after immersion in SBF for 1 day thus confirming their high surface reactivity, similar to undoped 45S5 BC. XRD results showed that the Li-doped BGs crystallize mainly to combeite (Na2Ca2Si3O9) and silicorhenanite (SiO4(PO4)(2)Ca-5) but also Li6P6O18 and Li3PO4 phases were detected. In terms of lithium ion release, the formulations at 2.5 wt.% and 5 wt.% Li2O content were the only ones to be within the therapeutic range (<83 ppm). (C) 2015 Elsevier B.V. All rights reserved.



How to cite
APA: Miguez Pacheco, V., Büttner, T., Macon, A.L.B., Jones, J.R., Fey, T., de Ligny, D.,... Boccaccini, A. (2016). Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair. Journal of Non-Crystalline Solids, 432, 65-72. https://dx.doi.org/10.1016/j.jnoncrysol.2015.03.027

MLA: Miguez Pacheco, Valentina, et al. "Development and characterization of lithium-releasing silicate bioactive glasses and their scaffolds for bone repair." Journal of Non-Crystalline Solids 432 (2016): 65-72.

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