Journal article
(Review article)


A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments


Publication Details
Author(s): Chen C, Ahmed M, Klämpfl F, Stelzle F, Schmidt M
Publisher: International Society for Optical Engineering; 1999
Publication year: 2015
Volume: 9792
Journal issue: 97920J
ISSN: 0277-786X
Language: English

Abstract

To provide clinically relevant insights into the device performance of an optical imaging approach to reconstruct the superficial cutaneous micro-circulation (skin angiography), a phantom device with turbid matrix and perfusable micro-vessels is essential. In this work, we describe a novel microfluidic-based device to mimic the micro-vessels and the turbid nature of the epidermis and dermis. This phantom device contains a hollow assay with a diameter of the channels of 50 μm. The hollow assay includes the geometry of the inlet, the river-like assay, and the outlet, which can be perfused by e.g. meta-hemoglobin solution. This imitates the superficial micro-circulation in the skin. The absorption coefficient μa and the reduced scattering coefficient μs' are adjusted to match those of skin. As an application case, we attempt to reconstruct a 2-D velocity field of the hemoglobin flow in the scattering microfluidic device via the Doppler-mode of an OCT.



How to cite
APA: Chen, C., Ahmed, M., Klämpfl, F., Stelzle, F., & Schmidt, M. (2015). A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments. Proceedings- Spie the International Society for Optical Engineering, 9792(97920J). https://dx.doi.org/10.1117/12.2203446

MLA: Chen, Chen, et al. "A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments." Proceedings- Spie the International Society for Optical Engineering 9792.97920J (2015).

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