A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments

Chen C, Ahmed M, Klämpfl F, Stelzle F, Schmidt M (2015)


Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2015

Journal

Publisher: International Society for Optical Engineering; 1999

Book Volume: 9792

Journal Issue: 97920J

DOI: 10.1117/12.2203446

Abstract

To provide clinically relevant insights into the device performance of an optical imaging approach to reconstruct the superficial cutaneous micro-circulation (skin angiography), a phantom device with turbid matrix and perfusable micro-vessels is essential. In this work, we describe a novel microfluidic-based device to mimic the micro-vessels and the turbid nature of the epidermis and dermis. This phantom device contains a hollow assay with a diameter of the channels of 50 μm. The hollow assay includes the geometry of the inlet, the river-like assay, and the outlet, which can be perfused by e.g. meta-hemoglobin solution. This imitates the superficial micro-circulation in the skin. The absorption coefficient μa and the reduced scattering coefficient μs' are adjusted to match those of skin. As an application case, we attempt to reconstruct a 2-D velocity field of the hemoglobin flow in the scattering microfluidic device via the Doppler-mode of an OCT.

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How to cite

APA:

Chen, C., Ahmed, M., Klämpfl, F., Stelzle, F., & Schmidt, M. (2015). A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments. Proceedings of SPIE, 9792(97920J). https://dx.doi.org/10.1117/12.2203446

MLA:

Chen, Chen, et al. "A novel microfluidic model to mimic turbid nature and microvasculature of cutaneous tissue for optical imaging experiments." Proceedings of SPIE 9792.97920J (2015).

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