Journal article
(Review article)


Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments


Publication Details
Author(s): Chen C, Klämpfl F, Knipfer C, Riemann M, Kanawade R, Stelzle F, Schmidt M
Publisher: Optical Society of America
Publication year: 2014
Volume: 5
Journal issue: 9
Pages range: 3140-3149
ISSN: 2156-7085
Language: English

Abstract

A popular alternative of preparing multilayer or microfluidic chip based phantoms could have helped to simulate the subsurface vascular network, but brought inevitable problems. In this work, we describe the preparation method of a single layer skin equivalent tissue phantom containing interior vessel channels, which mimick the superficial microvascular structure. The fabrication method does not disturb the optical properties of the turbiding matrix material. The diameter of the channels reaches a value of 50 μm. The size, as well as the geometry of the generated vessel structures are investigated by using the SD-OCT system. Our preliminary results confirm that fabrication of such a phantom is achievable and reproducible. Prospectively, this phantom is used to calibrate the optical angiographic imaging approaches.



How to cite
APA: Chen, C., Klämpfl, F., Knipfer, C., Riemann, M., Kanawade, R., Stelzle, F., & Schmidt, M. (2014). Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments. Biomedical Optics Express, 5(9), 3140-3149. https://dx.doi.org/10.1364/BOE.5.003140

MLA: Chen, Chen, et al. "Preparation of a skin equivalent phantom with interior micron-scale vessel structures for optical imaging experiments." Biomedical Optics Express 5.9 (2014): 3140-3149.

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