Journal article
(Review article)


Mapping the microvascular and the associated absolute values of oxyhemoglobin concentration through turbid media via local off-set diffuse optical imaging


Publication Details
Author(s): Chen C, Klämpfl F, Stelzle F, Schmidt M
Publisher: International Society for Optical Engineering; 1999
Publication year: 2014
Volume: 9268
Journal issue: 92680V
ISSN: 0277-786X
Language: English

Abstract

An imging resolution of micron-scale has not yet been discovered by diffuse optical imaging (DOI), while a superficial response was eliminated. In this work, we report on a new approach of DOI with a local off-set alignment to subvert the common boundary conditions of the modified Beer-Lambert Law (MBLL). It can resolve a superficial target in micron scale under a turbid media. To validate both major breakthroughs, this system was used to recover a subsurface microvascular mimicking structure under an skin equivalent phantom. This microvascular was included with oxy-hemoglobin solution in variant concentrations to distiguish the absolute values of CtRHb and CtHbO2 . Experimental results confirmed the feasibility of recovering the target vascular of 50 µm in diameter, and graded the values of the concentrations of oxy-hemoglobin from 10 g/L to 50 g/L absolutely. Ultimately, this approach could evolve into a non-invasive imaging system to map the microvascular pattern and the associated oximetry under a human skin in-vivo.



How to cite
APA: Chen, C., Klämpfl, F., Stelzle, F., & Schmidt, M. (2014). Mapping the microvascular and the associated absolute values of oxyhemoglobin concentration through turbid media via local off-set diffuse optical imaging. Proceedings- Spie the International Society for Optical Engineering, 9268(92680V). https://dx.doi.org/10.1117/12.2071572

MLA: Chen, Chen, et al. "Mapping the microvascular and the associated absolute values of oxyhemoglobin concentration through turbid media via local off-set diffuse optical imaging." Proceedings- Spie the International Society for Optical Engineering 9268.92680V (2014).

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