Journal article


Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study


Publication Details
Author(s): Cumming P, Maschauer S, Riss P, Grill E, Pischetsrieder M, Kuwert T, Prante O
Publisher: Springer Verlag (Germany)
Publication year: 2015
Volume: 17
Pages range: 521-528
ISSN: 1536-1632

Abstract

Purpose: Post-synaptic dopamine D2/3 receptors are reduced in animal models of obesity, and in obese humans, concordant with similar findings in habitual drug users. However, corresponding pre-synaptic changes in brain dopamine are less documented in obesity models. Therefore, we used positron emission tomography (PET) with the dopamine transporter (DAT) ligand N-(3-[18F]fluoropropyl)-2-β-carbomethoxy-3-β-(4′-methylphenyl) tropane ([18F]FP-CMT) to test the hypothesis that DAT availability is attenuated in adult fatty Zucker (FZ) rats versus lean littermates (LZ).



How to cite
APA: Cumming, P., Maschauer, S., Riss, P., Grill, E., Pischetsrieder, M., Kuwert, T., & Prante, O. (2015). Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study. Molecular Imaging and Biology, 17, 521-528. https://dx.doi.org/10.1007/s11307-014-0811-7

MLA: Cumming, Paul, et al. "Perturbed development of striatal dopamine transporters in fatty versus lean Zucker rats: a follow-up small animal PET study." Molecular Imaging and Biology 17 (2015): 521-528.

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