Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites

Vargas GE, Haro Durand LA, Cadena V, Romero M, Vera Mesones R, Mackovic M, Spallek S, Spiecker E, Boccaccini AR, Gorustovich AA (2013)

Publication Type: Journal article

Publication year: 2013

Journal

Publisher: Springer Verlag (Germany)

Book Volume: 24

Pages Range: 1261-1269

Journal Issue: 5

DOI: 10.1007/s10856-013-4892-7

Abstract

Angiogenesis is essential for tissue regeneration and repair. A growing body of evidence shows that the use of bioactive glasses (BG) in biomaterial-based tissue engineering (TE) strategies may improve angiogenesis and induce increased vascularization in TE constructs. This work investigated the effect of adding nano-sized BG particles (n-BG) on the angiogenic properties of bovine type I collagen/n-BG composites. Nano-sized (20-30 nm) BG particles of nominally 45S5 Bioglass composition were used to prepare composite films, which were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The in vivo angiogenic response was evaluated using the quail chorioallantoic membrane (CAM) as an model of angiogenesis. At 24 h post-implantation, 10 wt% n-BG containing collagen films stimulated angiogenesis by increasing by 41 % the number of blood vessels branch points. In contrast, composite films containing 20 wt% n-BG were found to inhibit angiogenesis. This experimental study provides the first evidence that addition of a limited concentration of n-BG (10 wt%) to collagen films induces an early angiogenic response making selected collagen/n-BG composites attractive matrices for tissue engineering and regenerative medicine. © Springer Science+Business Media New York 2013.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

Universidad Nacional de Salta Argentina (AR) Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long" (INTECIN) Argentina (AR)

How to cite

APA:

Vargas, G.E., Haro Durand, L.A., Cadena, V., Romero, M., Vera Mesones, R., Mackovic, M.,... Gorustovich, A.A. (2013). Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites. Journal of Materials Science: Materials in Medicine, 24(5), 1261-1269. https://dx.doi.org/10.1007/s10856-013-4892-7

MLA:

Vargas, Gabriela E., et al. "Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites." Journal of Materials Science: Materials in Medicine 24.5 (2013): 1261-1269.

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