Journal article
(Review article)


Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry


Publication Details
Author(s): Bidmon C, Frischmann M, Pischetsrieder M
Publisher: Elsevier
Publication year: 2007
Volume: 855
Pages range: 51-58
ISSN: 1570-0232

Abstract

Sugars and sugar degradation products readily react in vitro with guanine derivatives, resulting in the formation of DNA-bound advanced glycation end-products (DNA-AGEs). The two diastereomers of N2-(1-carboxyethyl)-2′-deoxyguanosine (CEdGA,B) and the cyclic adduct of methylglyoxal and 2′-deoxyguanosine (mdG) (N2-7-bis(1-hydroxy-2-oxopropyl)-2′-deoxyguanosine have also been detected in cultured cells and/or in vivo. LC-MS/MS methods have been developed to analyze sensitively DNA adducts in vitro and in vivo. In this paper, the chemical structures of possible DNA-AGEs and the application of LC-MS/MS to measure DNA-AGEs are reviewed. © 2006 Elsevier B.V. All rights reserved.



How to cite
APA: Bidmon, C., Frischmann, M., & Pischetsrieder, M. (2007). Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 855, 51-58. https://dx.doi.org/10.1016/j.Jchromb.2006.11.033

MLA: Bidmon, Clemens, Matthias Frischmann, and Monika Pischetsrieder. "Analysis of DNA-bound advanced glycation end-products by LC and mass spectrometry." Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 855 (2007): 51-58.

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