Assessment of protein glycation markers in infant formulas
Birlouez-Aragon I, Pischetsrieder M, Leclère J, Morales F, Hasenkopf K, Kientsch-Engel R, Ducauze CJ, Rutledge D (2004)
Publication Type: Journal article
Publication year: 2004
Journal
Publisher: Elsevier
Book Volume: 87
Pages Range: 253-259
Journal Issue: 2
DOI: 10.1016/j.foodchem.2003.11.019
Abstract
The typical formulation of infant formulas (IF) may enhance damage of proteins during spray drying or sterilization. Lactose reacts with amino groups of proteins resulting in the formation of lactulosyllysine (LL). The latter is further degraded to give advanced glycation end-products (AGEs). Furthermore, oxidation reactions, which are catalyzed by iron can further promote AGE formation. In this study, six parameters for protein modification were measured for 41 commercially available IF samples: lysine blockage, tryptophan degradation and LL formation by HPLC, the AGEs Nε- carboxymethyllysine (CML) and oxalic acid monoalkylamide (OMA) by ELISA. The FAST index was used as a rapid method for monitoring AGEs. IF showed increased lysine loss (6-fold), LL formation (2-3-fold) and AGEs levels (3-5 times) (CML, OMA, and FAST index) compared to similarly treated cow's milk, indicating more severe protein modifications in the former. Further studies on the technological processes are required to minimize heat-induced damage of IF during manufacturing. © 2004 Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Additional Organisation(s)
Involved external institutions
Roche Diagnostics GmbH
Germany (DE)
French National Institute for Agricultural Research / Institut Nationale de la Recherche Agronomique (INRA)
France (FR)
Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)
Spain (ES)
Germany (DE)
French National Institute for Agricultural Research / Institut Nationale de la Recherche Agronomique (INRA)
France (FR)
Spanish National Research Council / Consejo Superior de Investigaciones Científicas (CSIC)
Spain (ES)
How to cite
APA:
Birlouez-Aragon, I., Pischetsrieder, M., Leclère, J., Morales, F., Hasenkopf, K., Kientsch-Engel, R.,... Rutledge, D. (2004). Assessment of protein glycation markers in infant formulas. Food Chemistry, 87(2), 253-259. https://doi.org/10.1016/j.foodchem.2003.11.019
MLA:
Birlouez-Aragon, Inés, et al. "Assessment of protein glycation markers in infant formulas." Food Chemistry 87.2 (2004): 253-259.
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