How to Reduce 3-deoxyglucosone and Acetaldehyde in Peritoneal Dialysis Fluids
Zimmeck T, Tauer A, Fünfrocken M, Pischetsrieder M (2002)
Publication Type: Journal article
Publication year: 2002
Journal
Publisher: Multimed Inc.; 1999
Pages Range: 350-356
Journal Issue: 22
Abstract
◆ Objective: 3-Deoxyglucosone (3-DG) and acetaldehyde were found to be the major reactive carbonyl compounds in conventional heat-sterilized peritoneal dialysis fluids (PDFs). The aim of this study was to identify factors in the production of PDFs promoting or inhibiting the formation of acetaldehyde and 3-DG. ◆ Design: Single-chamber bag PDFs with different buffer systems and pH values were analyzed for acetaldehyde. 3-Deoxyglucosone was determined in double-chamber bag PDFs with different pH values, in commercially available samples, and in double-chamber products stored under defined conditions. ◆ Results: Acetaldehyde was found in the presence of lactate and malate, whereas in 2-hydroxybutanoate-buffered solution propionaldehyde was detected instead. Between pH 5.0 and 6.0 the acetaldehyde content in lactate-buffered solutions increased strongly.The concentration of 3-DG in the chamber containing glucose in double-chamber bags increased between pH 3.0 and 5.0 by a factor of 6.3-Deoxyglucosone concentrations in commercially available products vary greatly, reflecting the different pH values of these products. A time- and temperature-dependent reaction leads to a reduction in 3-DG and an increase in 5-hydroxymethyl-furan-2-carbaldehyde during storage. ◆ Conclusion: Acetaldehyde is produced by a reaction that requires both lactate and glucose. Thus, its formation can be prevented by a separation of the reaction partners, glucose and lactate, in a double-chamber bag. In double-chamber bags, pH greatly influences the formation of 3-13G. Minimal formation is observed in the region of pH 3.0. This finding should be taken into account for the development of new double-chamber bag PDFs.
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Germany (DE)How to cite
APA:
Zimmeck, T., Tauer, A., Fünfrocken, M., & Pischetsrieder, M. (2002). How to Reduce 3-deoxyglucosone and Acetaldehyde in Peritoneal Dialysis Fluids. Peritoneal Dialysis International, 22, 350-356.
MLA:
Zimmeck, Thomas, et al. "How to Reduce 3-deoxyglucosone and Acetaldehyde in Peritoneal Dialysis Fluids." Peritoneal Dialysis International 22 (2002): 350-356.
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