Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA

Blechinger J, Pieper H, Marzenell P, Kovbasyuk LA, Serva A, Starkuviene V, Erfle H, Mokhir A (2013)

Publication Type: Journal article, Original article

Publication year: 2013

Journal

Chemical Communications Royal Society of Chemistry

Original Authors: Blechinger J., Pieper H., Marzenell P., Kovbasyuk L., Serva A., Starkuviene V., Erfle H., Mokhir A.

Publisher: Royal Society of Chemistry

Book Volume: 49

Pages Range: 7397-7399

Journal Issue: 67

DOI: 10.1039/c3cc43174f

Abstract

We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers. © 2013 The Royal Society of Chemistry.

Authors with CRIS profile

Jenny Blechinger Professur für Organische Chemie Hanna Pieper Lehrstuhl für Organische Chemie II Andriy Mokhir Professur für Organische Chemie

Involved external institutions

Ruprecht-Karls-Universität Heidelberg DE Germany (DE)

How to cite

APA:

Blechinger, J., Pieper, H., Marzenell, P., Kovbasyuk, L.A., Serva, A., Starkuviene, V.,... Mokhir, A. (2013). Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA. Chemical Communications, 49(67), 7397-7399. https://dx.doi.org/10.1039/c3cc43174f

MLA:

Blechinger, Jenny, et al. "Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA." Chemical Communications 49.67 (2013): 7397-7399.

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