Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands

Hiller C, Kühhorn J, Gmeiner P (2013)


Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2013

Journal

Original Authors: Hiller C., Kuhhorn J., Gmeiner P.

Publisher: American Chemical Society

Book Volume: 56

Pages Range: 6542-6559

Journal Issue: 17

DOI: 10.1021/jm4004335

Abstract

G-protein-coupled receptors (GPCRs) represent the largest family of membrane proteins involved in cellular signal transduction and are activated by various different ligand types including photons, peptides, proteins, but also small molecules like biogenic amines. Therefore, GPCRs are involved in diverse physiological processes and provide valuable drug targets for numerous diseases. Emerging body of evidence suggests that GPCRs exist as monomers or cross-react forming dimers and higher-ordered oligomers. In this Perspective we will review current biochemical and biophysical techniques to visualize GPCR dimerization, functional consequences of homo- and heterodimers, and approaches of medicinal chemists to target these receptor complexes with homo- and heterobivalent ligands. © 2013 American Chemical Society.

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APA:

Hiller, C., Kühhorn, J., & Gmeiner, P. (2013). Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands. Journal of Medicinal Chemistry, 56(17), 6542-6559. https://dx.doi.org/10.1021/jm4004335

MLA:

Hiller, Christine, Julia Kühhorn, and Peter Gmeiner. "Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands." Journal of Medicinal Chemistry 56.17 (2013): 6542-6559.

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