Fassihi Dehkordi S, Schottenhamml J, Müller M, Hosari S, Lämmer R, Maier A, Hohberger B, Mardin C (2025)
Publication Type: Journal article
Publication year: 2025
Book Volume: 68
Pages Range: 372-380
Journal Issue: 1
DOI: 10.1159/000545878
Introduction: Peripapillary optical coherence tomography angiography (OCT-A) scans are a challenge for vessel density (VD) analysis, being dependent on demarcation of the optic disc. Longitudinal VD analysis requires that each pixel of the OCT-A scan must be at the exact same location during follow-up scans in order to see inter-visit differences. The aim of the present study was to investigate reliability of Bruch's membrane opening (BMO)-based peripapillary OCT-A analysis with and without the implementation of the anatomical positioning system (APS) compared to manual analysis. Methods: Thirty-seven eyes were measured twice by OCT-A (Heidelberg OCT II Spectralis) and analyzed by the Erlangen-Angio-Tool (EA-Tool) with an APS- and BMO-based analysis of the macula and peripapillary region. APS allows alignment of OCT-A scans according to each individual FoBMOC (fovea-to-Bruch's membrane opening center). Peripapillary OCT-A scans were analyzed: (1) manually (by the shortest distance of the vertical or horizontal diameter of the optic disc), (2) BMO-based, and (3) BMO-based with APS information. Coefficients of variation (CVs) were calculated. Results: Peripapillary mean VD was 42.52 ± 4 and 41.69 ± 4 (manually), 50.29 ± 4 and 48.8 ± 4 (BMO-based), and 44.73 ± 3 and 44.39 ± 4 (BMO-based and APSified) for 1st and 2nd scan, respectively. Peripapillary mean VD yielded a significant difference between the 1st and 2nd scan for manual (p = 0.04), but not for BMO-based (p > 0.05) and BMO-based and APSified analysis (p > 0.05). CVs were 10.0% (manually), 8.0% (BMO-based), and 8.0% (BMO-based and APSified). Conclusion: The integration of BMO and APS information into the EA-Tool allows a BMO-based peripapillary VD analysis for longterm OCT-A analysis.
APA:
Fassihi Dehkordi, S., Schottenhamml, J., Müller, M., Hosari, S., Lämmer, R., Maier, A.,... Mardin, C. (2025). Bruch's Membrane Opening-Based Peripapillary Optical Coherence Tomography Angiography Analysis. Ophthalmic Research, 68(1), 372-380. https://doi.org/10.1159/000545878
MLA:
Fassihi Dehkordi, Sebastian, et al. "Bruch's Membrane Opening-Based Peripapillary Optical Coherence Tomography Angiography Analysis." Ophthalmic Research 68.1 (2025): 372-380.
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