The influence of light on Interleukin-10: A preliminary study

Mekschrat L, Göring M, Schmalbach B, Rohleder N, Petrowski K (2024)

Publication Type: Journal article

Publication year: 2024

Journal

Brain, Behavior, & Immunity-Health Elsevier

Book Volume: 42

Article Number: 100887

DOI: 10.1016/j.bbih.2024.100887

Abstract

Light influences circadian rhythms, including that of the stress hormone cortisol. Cortisol, in turn, has been observed to promote expression of the anti-inflammatory cytokine IL-10. It is thus of interest whether the cytokine IL-10 is also influenced by light, perhaps in accord with the diurnal variations in cortisol. Hence, this highly standardized preliminary sleep laboratory study in healthy adult men investigated a potential influence of different light exposure on IL-10 and cortisol concentrations in blood. In a between-subject design, N = 42 participants were exposed to either bright, dim, blue or red light after wake-up. Two mixed-model analyses with the factors of light condition and time (across eight IL-10 and cortisol sampling points) were conducted. Additionally, area under the curve measurements (AUCg and AUCi) were calculated for both cortisol and IL-10. Across all conditions, IL-10 and cortisol concentrations significantly changed over time. However, none of the light conditions exerted a greater influence on IL-10 or cortisol levels than others. For cortisol, there was greater total output (AUCg) in the blue-light condition in particular. Further research is needed to gain insight into whether or not types of light or cortisol levels have a hand in influencing natural IL-10 concentrations.

Authors with CRIS profile

Nicolas Rohleder Lehrstuhl für Gesundheitspsychologie

Involved external institutions

Universitätsmedizin der Johannes Gutenberg-Universität Mainz DE Germany (DE)

How to cite

APA:

Mekschrat, L., Göring, M., Schmalbach, B., Rohleder, N., & Petrowski, K. (2024). The influence of light on Interleukin-10: A preliminary study. Brain, Behavior, & Immunity-Health, 42. https://doi.org/10.1016/j.bbih.2024.100887

MLA:

Mekschrat, Liza, et al. "The influence of light on Interleukin-10: A preliminary study." Brain, Behavior, & Immunity-Health 42 (2024).

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