Modelling and Construction of Complex Shaped Polyvinyl Alcohol based Ultrasound Phantoms for Inverse Magnetomotive Ultrasound Imaging

Heim C, Huber C, Ermert H, Ullmann I, Saleem T, Lyer S, Rupitsch SJ (2024)

Publication Language: German

Publication Type: Conference contribution, Conference Contribution

Publication year: 2024

Event location: Nürnberg DE

DOI: 10.5162/sensoren2024/D1.4

Abstract

With regard to the application in local cancer treatment, the inverse magnetomotive ultrasound (IMMUS) modality needs to be extended to 3D on complex shaped polyvinyl alcohol (PVA) phantoms. Our four basic construction elements can be combined step-by-step to manufacture such complex shaped phantoms. The construction of complex shaped ultrasound phantoms requires the four basic elements (i) molds, (ii) scattering material, (iii) layering process, and (iv) mechanical coupling between different parts of the phantom. In this contribution, we describe the construction elements in detail to show the trade-offs between the possible shapes and positioning of the encapsulated volumes and the production time. Furthermore, since IMMUS requires knowledge of the mechanical parameters and the geometry of the target tumorous tissue, these parameters have to be determined during a magnetic drug targeting (MDT) therapy. The insertion of MDT therapy relevant amount of superparamagnetic iron oxide nanoparticles (SPIONs) does not significantly change the material properties. Therefore, quantitative ultrasound-based tissue characterization techniques (UTCT) such as shear wave elastography (SWE) or transient elastography (TE) can be used to characterize the target tumorous tissue once in advance of an MDT therapy. In this contribution, SWE and TE are exploited to determine shear wave velocity in PVA phantoms. Both methods show promising results for the determination of Young's modulus.

Authors with CRIS profile

Christian Huber Department of Otorhinolaryngology – Head and Neck Surgery (HNO-Klinik) Helmut Ermert Professur für Nanomedizin Ingrid Ullmann Lehrstuhl für Hochfrequenztechnik (LHFT) Stefan Lyer Professur für KI-gesteuerte Nanomaterialien Stefan Rupitsch

Involved external institutions

Albert-Ludwigs-Universität Freiburg DE Germany (DE)

How to cite

APA:

Heim, C., Huber, C., Ermert, H., Ullmann, I., Saleem, T., Lyer, S., & Rupitsch, S.J. (2024). Modelling and Construction of Complex Shaped Polyvinyl Alcohol based Ultrasound Phantoms for Inverse Magnetomotive Ultrasound Imaging. In Tagungsband 22. GMA/ITG-Fachtagung Sensoren und Messsysteme 2024. Nürnberg, DE.

MLA:

Heim, Christian, et al. "Modelling and Construction of Complex Shaped Polyvinyl Alcohol based Ultrasound Phantoms for Inverse Magnetomotive Ultrasound Imaging." Tagungsband 22. GMA/ITG-Fachtagung Sensoren und Messsysteme 2024, Nürnberg 2024.

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