IL-3: key orchestrator of inflammation

Podolska M, Grützmann R, Pilarsky C, Benard A (2024)

Publication Language: English

Publication Type: Journal article, Review article

Publication year: 2024

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 15

Article Number: 1411047

DOI: 10.3389/fimmu.2024.1411047

Abstract

Interleukin (IL)-3 has long been known for its hematopoietic properties. However, recent evidence has expanded our understanding of IL-3 function by identifying IL-3 as a critical orchestrator of inflammation in a wide array of diseases. Depending on the type of disease, the course of inflammation, the cell or the tissue involved, IL-3 promotes either pathologic inflammation or its resolution. Here, we describe the cell-specific functions of IL-3 and summarize its role in diseases. We discuss the current treatments targeting IL-3 or its receptor, and highlight the potential and the limitations of targeting IL-3 in clinics.

Authors with CRIS profile

Malgorzata Podolska Department of Surgery Robert Grützmann Lehrstuhl für Allgemein- und Viszeralchirurgie Christian Pilarsky Professur für Chirurgische Forschung Alan Benard Department of Surgery

How to cite

APA:

Podolska, M., Grützmann, R., Pilarsky, C., & Benard, A. (2024). IL-3: key orchestrator of inflammation. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1411047

MLA:

Podolska, Malgorzata, et al. "IL-3: key orchestrator of inflammation." Frontiers in Immunology 15 (2024).

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