An Empirical Survey on the Adaption of Neoadjuvant Chemotherapy in Bladder Cancer
Reike MJ, Reicherz A, Tully KH, Bahlburg H, Maas M, Bach P, Klümper N, Eckstein M, Hartmann A, Breyer J, Erben P, Bolenz C, Noldus J, Berg S, Roghmann F (2024)
Publication Type: Journal article
Publication year: 2024
Journal
Pages Range: 183-189
DOI: 10.1159/000536321
Abstract
Introduction: The aim of the study was to determine the adaption of neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC) in Germany, Austria, and Switzerland and especially underlying reasons for potential low adherence to guidelines. Methods: We conducted a non-validated survey among 336 urologic departments in Germany, Austria, and Switzerland. RedCap questionnaires were electronically distributed and included 23 items concerning the general NAC administration standards and guideline compliance in patient counseling regarding the actual treatment. Results: The return rate of the questionnaire was 19.1% (63/336). Although 45 departments (71.4%) claim to perform NAC as the standard of care, only 49% of eligible patients actually receive NAC. An advanced disease stage (>cT3) and a high tumor volume were mentioned to support the application of NAC, whereas 35% of responders worry about deterioration of patients preoperative status due to NAC. Furthermore, 26.7% of respondents are concerned about the low extent of survival benefit. Conclusion: Application of NAC in eligible MIBC patients in Germany, Austria, and Switzerland remains low. Although the majority of urologic departments discuss NAC and acknowledge the need for intensified treatment in advanced disease stages, not all eligible patients will actually receive NAC before radical cystectomy.
Authors with CRIS profile
Markus Eckstein
Institute of Pathology
Arndt Hartmann
Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Involved external institutions
Universitätsklinikum Mannheim
Germany (DE)
Universitätsklinikum Ulm
Germany (DE)
St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universität Regensburg
Germany (DE)
Germany (DE)
Universitätsklinikum Ulm
Germany (DE)
St. Elisabeth Gruppe GmbH - Katholische Kliniken Rhein-Ruhr
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Universität Regensburg
Germany (DE)
How to cite
APA:
Reike, M.J., Reicherz, A., Tully, K.H., Bahlburg, H., Maas, M., Bach, P.,... Roghmann, F. (2024). An Empirical Survey on the Adaption of Neoadjuvant Chemotherapy in Bladder Cancer. Urologia Internationalis, 183-189. https://doi.org/10.1159/000536321
MLA:
Reike, Moritz J., et al. "An Empirical Survey on the Adaption of Neoadjuvant Chemotherapy in Bladder Cancer." Urologia Internationalis (2024): 183-189.
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